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Articles

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  1. Adherent-invasive Escherichia coli (AIEC) is linked to intestinal inflammation in inflammatory bowel disease (IBD). Arthrospira platensis and Lactobacillus helveticus exhibit anti-inflammatory properties individu...

    Authors: Samira Alipour, Hossein Halimi, Nastaran Asri, Mohammad Rostami-Nejad, Leila Pishkar and Hamidreza Houri
    Citation: BMC Molecular and Cell Biology 2025 26:20
    Content type: Research Published on:

  3. Short-chain 3-hydroxyacyl-CoA dehydrogenase (SCHAD) is a ubiquitously expressed mitochondrial enzyme with a role in the degradation of fatty acids. Because the protein also is a negative regulator of insulin s...

    Authors: Kelly Velasco, Janniche Torsvik, Johanna L. St-Louis, Sarah Baghestani, Jonas S. G. Silvander, Rohit N. Kulkarni, Diana M. Toivola and Anders Molven
    Citation: BMC Molecular and Cell Biology 2025 26:18
    Content type: Research Published on:

  4. HIV infection is mainly described by depletion of CD4+ T-cells; however, this not only occurs in infected cells, also arise in uninfected immunological cells through the bystander effect. Extrinsic cell death, in...

    Authors: Sarah Ratkovich-Gonzalez, Mariana Del Rocio Ruiz-Briseño, Judith Carolina De Arcos-Jiménez, Monserrat Alvarez-Zavala, Jaime Federico Andrade-Villanueva, Pedro Martínez-Ayala, Vida V. Ruíz-Herrera, Luz Alicia Gonzalez-Hernandez and Karina Sánchez-Reyes
    Citation: BMC Molecular and Cell Biology 2025 26:17
    Content type: Research Published on:

  5. Protein folding is a complex process in which amino acid sequences encode the information required for a polypeptide chain to fold into its functional three-dimensional (3D) structure. Many proteins share comm...

    Authors: K. M. Ahsanul Kabir, Takuya Takahashi and Takeshi Kikuchi
    Citation: BMC Molecular and Cell Biology 2025 26:16
    Content type: Research Published on:

  6. Mesenchymal stem cells (MSCs) are promising for cell-based therapies targeting a wide range of diseases. However, challenges in translating MSC-based therapies to clinical applications necessitate standardized...

    Authors: Michael E. Williams, Federica Banche Niclot, Sara Rota, Jaesang Lim, Janaina Machado, Ricardo de Azevedo, Katia Castillo, Samuel Adebiyi, Ranga Sreenivasan, Daniel Kota, Patrick C. Mcculloch and Francesca Taraballi
    Citation: BMC Molecular and Cell Biology 2025 26:15
    Content type: Research Published on:

  7. Esophageal squamous cell carcinoma (ESCC), one of the most aggressive carcinomas of the gastrointestinal tract, is the sixth most common cause of cancer-related death. Wnt pathway plays a pivotal role in cell ...

    Authors: Fereshteh Ahmadian Shalchi, Nayyerehalsadat Hosseini, Fatemeh Nourmohammadi, Mohammad Arian Ahmadian Shalchi and Mohammad Mahdi Forghanifard
    Citation: BMC Molecular and Cell Biology 2025 26:14
    Content type: Research Published on:

  8. Cells constantly sense and respond to changes in their local environment to adapt their behaviour and morphology. These external stimuli include chemical and mechanical signals, and much recent work has reveal...

    Authors: Joshua D. Clugston, Sarah Fox, James L. Harden and John W. Copeland
    Citation: BMC Molecular and Cell Biology 2025 26:13
    Content type: Research Published on:

  9. Phthalates are plasticizers that cause inflammation in several cell types and adversely affect the health of humans and animals. Nacetylcysteine (NAC) has been shown to exert antioxidant effects in various dis...

    Authors: Jin Hee Kim, Jae Hoon Lee, Yoon Jung Koo and Jong Wook Song
    Citation: BMC Molecular and Cell Biology 2025 26:12
    Content type: Research Published on:

  11. Dual leucine zipper kinase (DLK) is critical for neurite outgrowth in the developing nervous system and during nerve regeneration, but the underlying mechanisms remain largely unknown. To address this issue, w...

    Authors: Guillaume St-Cyr, Daniel Garneau, Nicolas Gévry and Richard Blouin
    Citation: BMC Molecular and Cell Biology 2025 26:10
    Content type: Research Published on:

  12. The production of functional hepatocyte cells in enough quantities is of paramount importance for the replacement of lost hepatocytes. In this investigation, a series of 7-mimic microRNAs was harnessed to indu...

    Authors: Afsoon Afshari, Negar Azarpira and Sara Pakbaz
    Citation: BMC Molecular and Cell Biology 2025 26:9
    Content type: Research Published on:

  13. The reactivation and loss of mosaicism hypothesis due to X chromosome inactivation (XCI) skewing and escape could influence gender differences in autoimmune diseases. XCI selectively inactivates one of the two...

    Authors: In-Cheol Baek, Soo Yeun Sim, Byung-Kyu Suh, Tai-Gyu Kim and Won Kyoung Cho
    Citation: BMC Molecular and Cell Biology 2025 26:8
    Content type: Research Published on:

  14. This paper describes a method for determining the cytotoxicity of chemical compounds based on the detection of fluorescent proteins—in this case, green fluorescent protein (GFP) and red fluorescent protein (RF...

    Authors: Dmitry Lifanov, Dulamsuren Zorigt, Evgenya Shabalina, Abdullah Khalil, Konstantin Gorbunov and Elena Petersen
    Citation: BMC Molecular and Cell Biology 2025 26:7
    Content type: Research Published on:

  15. Papillary thyroid carcinoma (PTC) is a common malignant tumor. BRAFV600E mutation has become a common molecular event in PTC pathogenesis. Circular RNA PSD3 (circPSD3) is known to be highly expressed in PTC. Howe...

    Authors: Chuang Li, Xiaojuan Zhao, Jingge Zhao, Jing Zhao, Lemei An and Gang Wu
    Citation: BMC Molecular and Cell Biology 2025 26:6
    Content type: Research Published on:

  16. Bioengineering of human teeth for replacement is an appealing regenerative approach in the era of gene therapy. Developmentally regulated transcription factors hold promise in the quest because these transcrip...

    Authors: Camila Sabatini, Huey-Jiun Lin, Galib Ovik, Richard Hall and Techung Lee
    Citation: BMC Molecular and Cell Biology 2025 26:5
    Content type: Research Published on:

  19. During the latter stages of their development, mammalian oocytes under dramatic chromatin reconfiguration, transitioning from a non-surrounded nucleolus (NSN) to a surrounded nucleolus (SN) stage, and concomit...

    Authors: Hannah Demond, Soumen Khan, Juan Castillo-Fernandez, Courtney W. Hanna and Gavin Kelsey
    Citation: BMC Molecular and Cell Biology 2025 26:2
    Content type: Research Published on:

  20. Inactivation or mutations of FAM20C causes human Raine Syndrome, which manifests as lethal osteosclerosis bone dysplasia or non-lethal hypophosphatemia rickets. However, it is only hypophosphatemia rickets that w...

    Authors: Mengnan Chen, Dongmei Sun, Siu-Pok Yee, Zhaoyang Yuan, Li Lin, Bing Cui, Yi Wang, Chao Liu and Peihong Liu
    Citation: BMC Molecular and Cell Biology 2025 26:1
    Content type: Research Published on:

  21. Cystic echinococcosis (CE) is a worldwide zoonotic public health issue. The reasons for this include a lack of specific therapy options, increasing antiparasitic drug resistance, a lack of control strategies, ...

    Authors: Jadoon Khan, Asma Sadiq, May M. Alrashed, Nosheen Basharat, Syed Nadeem Ul Hassan Mohani, Tawaf Ali Shah, Kotb A. Attia, Aamer Ali Shah, Hayat Khan, Ijaz Ali and Arif Ahmed Mohammed
    Citation: BMC Molecular and Cell Biology 2024 25:29
    Content type: Research Published on:

  22. In recent years, chondrocytes have been found to contain hemoglobin, which might be an alternative strategy for adapting to the hypoxic environment, while the potential mechanisms of that is still unclear. Her...

    Authors: Zhihao Zhang, Ting He, Hongwen Gu, Yuanhang Zhao, Shilei Tang, Kangen Han, Yin Hu, Hongwei Wang and Hailong Yu
    Citation: BMC Molecular and Cell Biology 2024 25:28
    Content type: Research Published on:

  23. Alanine-rich, alpha-helical type I antifreeze proteins (AFPs) in fishes are thought to have arisen independently in the last 30 Ma on at least four occasions. This hypothesis has recently been proven for floun...

    Authors: Laurie A. Graham and Peter L. Davies
    Citation: BMC Molecular and Cell Biology 2024 25:27
    Content type: Research Published on:

  24. Cellular senescence is a key driver of decreased bone formation and osteoporosis. Leptin (LEP) has been implicated in cellular senescence and osteogenic differentiation. The aim of this study was to investigat...

    Authors: Zhuang Zhang, Chaoqing Zhou and Lili Yu
    Citation: BMC Molecular and Cell Biology 2024 25:26
    Content type: Research Published on:

  26. Malignant gliomas exhibit rapid tumor progression and resistance to treatment, leading to high lethality. One of the causes is the reduced progression of apoptosis in glioma cells. Layilin is a type 1 transmem...

    Authors: Mitsumi Arito, Atsuhiro Tsutiya, Masaaki Sato, Kazuki Omoteyama, Toshiyuki Sato, Yusei Motonaga, Naoya Suematsu, Manae S. Kurokawa and Tomohiro Kato
    Citation: BMC Molecular and Cell Biology 2024 25:24
    Content type: Research Published on:

  27. The main characteristic of asthma is chronic inflammation. We examined cellular senescence by histology and molecular assay in the lungs of a rat model of asthma. This model comprises sensitization by several ...

    Authors: Majid Hassanzadeh-Khanmiri, Rana Keyhanmanesh, Reza Mosaddeghi-Heris, Aref Delkhosh, Jafar Rezaie, Sajjad Taghizadeh, Mehdi Rezai Seghin Sara and Mahdi Ahmadi
    Citation: BMC Molecular and Cell Biology 2024 25:23
    Content type: Research Published on:

  28. Retinal ischemia–reperfusion (IR) injury is a basic pathological procedure in clinic and associated with various ischemic retinal diseases, including glaucoma, diabetic retinopathy, retinal vascular occlusion,...

    Authors: Enming Du, Xiaolin Jia, Xiaoli Li, Beibei Zhang, Yaping Zhai and Fangyuan Qin
    Citation: BMC Molecular and Cell Biology 2024 25:22
    Content type: Research Published on:

  29. Bacillus strains are well recognized for their inherent production of bioactive compounds that exhibit antibacterial and anticancer properties. This study aims to evaluate the antimicrobial and anticancer effects...

    Authors: Ahmadreza Shahniani, Zahra Bamzadeh, Fahimeh Mahmoudnia and Leila Rouhi
    Citation: BMC Molecular and Cell Biology 2024 25:21
    Content type: Research Published on:

  30. Cryopreservation is a crucial procedure for safeguarding cells or other biological constructs, showcasing considerable potential for applications in tissue engineering and regenerative medicine.

    Authors: Hafiz Muhaymin Mohamed, Piraveenraj Sundar, Nur Aisyah Ahmad Ridwan, Ai Jia Cheong, Nur Atiqah Mohamad Salleh, Nadiah Sulaiman, Fauzi Mh Busra and Manira Maarof
    Citation: BMC Molecular and Cell Biology 2024 25:20
    Content type: Research Published on:

  31. Hepatitis B virus (HBV) infection poses a substantial threat to human health, impacting not only infected individuals but also potentially exerting adverse effects on the health of their offspring. The underly...

    Authors: Baoyan Wu, Yuying Sheng, Wenwei Yu, Lewen Ruan, Hao Geng, Chuan Xu, Chao Wang, Dongdong Tang, Mingrong Lv, Rong Hua and Kuokuo Li
    Citation: BMC Molecular and Cell Biology 2024 25:19
    Content type: Research Published on:

  32. Circulating microRNAs have been implicated in a diverse array of biological and pathological phenomena. Their potential utility as noninvasive biomarkers for screening and diagnosing various diseases has been ...

    Authors: Hadeel A. Al-Rawaf, Sami A. Gabr, Amir Iqbal and Ahmad H. Alghadir
    Citation: BMC Molecular and Cell Biology 2024 25:18
    Content type: Research Published on:

  34. Oxidative stress is implicated in the pathogenesis of heart failure. Dual oxidase 1 (DUOX1) might be important in heart failure development through its mediating role in oxidative stress. This study was design...

    Authors: Yan Song Li, Jingwen Xia, Chang Yuan Chen, Shu Hong Ren and Mao Rong He
    Citation: BMC Molecular and Cell Biology 2024 25:16
    Content type: Research Published on:

  35. Transfection is an important analytical method for studying gene expression in the cellular environment. There are some barriers to efficient DNA transfection in host cells, including circumventing the plasma ...

    Authors: Parisa Jamour, Abbas Jamali, Arash Ghalyanchi Langeroudi, Behrouz Ebadi Sharafabad and Asghar Abdoli
    Citation: BMC Molecular and Cell Biology 2024 25:15
    Content type: Research Published on:

  36. Emerging evidence underscores the responsiveness of the mammalian intestine to dietary cues, notably through the involvement of LGR5 + intestinal stem cells in orchestrating responses to diet-driven signals. H...

    Authors: Itsuma Nagao and Yoko M. Ambrosini
    Citation: BMC Molecular and Cell Biology 2024 25:14
    Content type: Research Published on:

  37. Sepsis-induced small-intestinal injury is associated with increased morbidity and mortality. Our previous study and other papers have shown that HIF-1α has a protective effect on intestinal mucosal injury in s...

    Authors: Zeyong Huang, Wenbin Teng, Liuxu Yao, Kai Xie, Suqin Hang, Rui He and Yuhong Li
    Citation: BMC Molecular and Cell Biology 2024 25:13
    Content type: Research Published on:

  38. Hormone receptor (HR)-positive breast cancer can become aggressive after developing hormone-treatment resistance. This study elucidated the role of long non-coding RNA (lncRNA) SOX2OT in tamoxifen-resistant (T...

    Authors: Jeeyeon Lee, Eun-Ae Kim, Jieun Kang, Yee Soo Chae, Ho Yong Park, Byeongju Kang, Soo Jung Lee, In Hee Lee, Ji-Young Park, Nora Jee-young Park and Jin Hyang Jung
    Citation: BMC Molecular and Cell Biology 2024 25:12
    Content type: Research Published on:

  39. Disruption of circadian rhythms is associated with neurological, endocrine and metabolic pathologies. We have recently shown that mice lacking functional type 3 deiodinase (DIO3), the enzyme that clears thyroi...

    Authors: Zhaofei Wu, M. Elena Martinez and Arturo Hernandez
    Citation: BMC Molecular and Cell Biology 2024 25:11
    Content type: Research Published on:

  40. OP9 mouse stromal cell line has been widely used to induce differentiation of human embryonic stem cells (hESCs) into hematopoietic stem/progenitor cells (HSPCs). However, the whole co-culture procedure usuall...

    Authors: Xin-xing Jiang, Meng-yi Song, Qi Li, Yun-jian Wei, Yuan-hua Huang and Yan-lin Ma
    Citation: BMC Molecular and Cell Biology 2024 25:10
    Content type: Research Published on:

  41. The alveolar epithelium is exposed to numerous stimuli, such as chemicals, viruses, and bacteria that cause a variety of pulmonary diseases through inhalation. Alveolar epithelial cells (AECs) cultured in vitr...

    Authors: Ikuya Tanabe, Kanae Ishimori and Shinkichi Ishikawa
    Citation: BMC Molecular and Cell Biology 2024 25:9
    Content type: Research Published on:

  42. Hypertension-induced mechanical stress on vascular smooth muscle cells (VSMCs) is a known risk factor for vascular remodeling, including vascular calcification. Caveolin-1 (Cav-1), an integral structural compo...

    Authors: Mohammad Shaver, Kassandra Gomez, Katherine Kaiser and Joshua D. Hutcheson
    Citation: BMC Molecular and Cell Biology 2024 25:8
    Content type: Research Published on:

  43. In recent years, the role of autophagy has been highlighted in the pathogenesis of diabetes and inflammatory lung diseases. In this study, using a diabetic model of mice, we investigated the expression of auto...

    Authors: Jafar Rezaie, Mojtaba Jahanghiri, Reza Mosaddeghi- Heris, Sina Hassannezhad, Nima Abdyazdani, Afshin Rahbarghazi and Mahdi Ahmadi
    Citation: BMC Molecular and Cell Biology 2024 25:7
    Content type: Research Published on:

  44. Macrophages promote angiogenesis, metastasis, and drug resistance in several cancers. Similarly, TonEBP/NFAT5 induces metastasis in renal carcinoma and colon cancer cells. However, the role of this transcripti...

    Authors: Hee Ju Song, Young Hwan Kim, Han Na Choi, Taehee Kim, Soo Jin Kim, Min Woong Kang and Sang Do Lee
    Citation: BMC Molecular and Cell Biology 2024 25:6
    Content type: Research Published on:

  45. Combination therapies in cancer treatment have demonstrated synergistic or additive outcomes while also reducing the development of drug resistance compared to monotherapy. This study explores the potential of...

    Authors: Tito N. Habib, Mohammed O. Altonsy, Salah A. Ghanem, Mohamed S. Salama and Mai A. Hosny
    Citation: BMC Molecular and Cell Biology 2024 25:5
    Content type: Research Published on:

  46. The lack of appropriate prognostic biomarkers remains a significant obstacle in the early detection of Head and Neck Squamous Cell Carcinoma (HNSCC), a cancer type with a high mortality rate. Despite considera...

    Authors: Md. Mizanur Rahman, Muhammad Mosaraf Hossain, Shafiqul Islam, Ridwan Ahmed, Mohit Majumder, Shantu Dey, Md. Kawser, Bishu Sarkar, Md. Ejajur Rahman Himu, Ali Asgar Chowdhury, Shakera Ahmed, Supran Biswas, Mostafa Mahfuzul Anwar, Mohammad Jamal Hussain, Rajib Kumar Shil, Sunanda Baidya…
    Citation: BMC Molecular and Cell Biology 2024 25:4
    Content type: Research Published on:

  47. Trypanosoma brucei is the causative agent for trypanosomiasis in humans and livestock, which presents a growing challenge due to drug resistance. While identifying novel drug targets is vital, the process is dela...

    Authors: Naghmeh Poorinmohammad and Reza Salavati
    Citation: BMC Molecular and Cell Biology 2024 25:3
    Content type: Research Published on:

  48. Fas-associated factor 1 (FAF1) is a multidomain protein that interacts with diverse partners to affect numerous cellular processes. Previously, we discovered two Small Ubiquitin-like Modifier (SUMO)-interactin...

    Authors: Chang-Han Chen, Hung-Wei Lin, Meng-Fang Huang, Chi-Wu Chiang, Kuen-Haur Lee, Nguyen Thanh Phuong, Zong-Yan Cai, Wen-Chang Chang and Ding-Yen Lin
    Citation: BMC Molecular and Cell Biology 2024 25:2
    Content type: Research Published on:

  49. Chronic alcohol exposure increases liver damage such as lipid accumulation and hepatitis, resulting in hepatic cirrhosis. Chronic alcohol intake is known to disturb circadian rhythms in humans and animals. DEC...

    Authors: Fuyuki Sato, Ujjal K. Bhawal, Kosuke Oikawa and Yasuteru Muragaki
    Citation: BMC Molecular and Cell Biology 2024 25:1
    Content type: Research Published on:

  50. Mitochondria are key cytoplasmic organelles in eukaryotic cells that generate adenosine triphosphate (ATP) through the electron transport chain and oxidative phosphorylation. Mitochondrial DNA (mtDNA) copy num...

    Authors: Mingyue Li, Keming Yang, Immaculata De Vivo, A. Heather Eliassen, Abrar A. Qureshi, Hongmei Nan and Jiali Han
    Citation: BMC Molecular and Cell Biology 2023 24:35
    Content type: Research Published on:
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