Fig. 4
From: PYGO2 regulates IL10 and plays immunosuppressive role through ESCC progression
Potential correlation between PYGO2 and IL10 expression through the Wnt/β-catenin signaling pathway in ESCC progression. Binding of Wnt ligand to FZD and LRP induces inactivation of the AXIN-APC-GSK3β destruction complex via DVL, leading to β-catenin accumulation and transition to the nucleus. Then, PYGO2 as a coactivator of the transcriptional complex (LEF/TCF/β-catenin), may directly activate transcription of target genes such as IL10. Furthermore, IL10 expression manifests direct correlation with FZD, WNT, LRP expression, β-catenin accumulation, and augmentation of EGFR levels in this pathway