Fig. 3
From: The formin FMNL2 plays a role in the response of melanoma cells to substrate stiffness
Cell motility is decreased with increased modulus. (A–E) Histograms of the net distance D travelled across all substrates for control (blue) and FMNL2 knockdown (orange) A2058 cells, with the overlap region shown in gray. Knockdown cells show a smaller average distance travelled than control cells as indicated by the shift in the histogram. Values are derived from cells tracked by live-cell imaging from the experiments shown in Fig. 1F A line graph showing the average distance travelled for all control and knockdown cells with increasing substrate stiffness. The error bars are the SEM. N = 3, with approximately 1000 cells analyzed per substrate