Fig. 4
From: Mutant Fam20c knock-in mice recapitulate both lethal and non-lethal human Raine Syndrome
The plain X-ray features of the conventional Fam20cD446N knock-in mice died before weaning. (A) The plain X-ray images of the P18d WT, conditional Fam20cD446N knock-in mice and the died conventional Fam20cD446N knock-in mice. (B-D) There were occasional death (less than 5%) from P1W to weaning in all conventional Fam20cD446N knock-in mice. The increased X-ray reflection was detected in the cranial bases (B), ribs (C) and femurs (D) of the occasionally died conventional Fam20cD446N knock-in mice. (Red arrowheads pointed to cranial bases, yellow arrowheads to ribs, blue arrowheads to cortex in tibiae and green arrowheads to tail vertebrates) (E) The reconstructed cortex and trabeculae in tibiae from P24d WT, conditional Fam20cD446N knock-in mice, as well as the survived and the died conventional Fam20cD446N knock-in mice. (F) The masson staining of the tibiae from P24d WT, conditional Fam20cD446N knock-in mice, as well as the survived and the died conventional Fam20cD446N knock-in mice. (Green arrowheads pointed to the cortex in tibiae; Scale bar is 200 μm)