Fig. 2
From: Mutant Fam20c knock-in mice recapitulate both lethal and non-lethal human Raine Syndrome
The skeletal characteristics of the conditional and conventional Fam20cD446N knock-in mice. (A) The gross views of the P2W WT, conditional and conventional Fam20cD446N knock-in mice (left) and the P4W WT, conditional and conventional Fam20cD446N knock-in mice (middle and right). (B) The statistical analysis on the body weights of P4W WT (17.14 ± 1.30 g), conditional (13.04 ± 1.57 g) and conventional Fam20cD446N knock-in (12.38 ± 1.20 g) mice. (**p < 0.01,*** p < 0.001). (C) Comparison of the plain X-ray examination on the femurs between P4W WT and conditional Fam20cD446N knock-in mice (most left); between P4W WT and conventional Fam20cD446N knock-in mice (the second image from left), between P8W WT and conditional Fam20cD446N knock-in mice (the second image from right), and among P8W WT, conditional Fam20c knock-out (KO) and conventional Fam20cD446N knock-in mice (most right). (Arrowheads delineated growth plates and arrows pointed to tibia cortex)