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Fig. 2 | BMC Molecular and Cell Biology

Fig. 2

From: Single-cell RNA sequencing identifies the expression of hemoglobin in chondrocyte cell subpopulations in osteoarthritis

Fig. 2

Subclustering of control and osteoarthritis (OA) group chondrocytes and characteristics of HBB expression in chondrocytes. A-B. Subclustering of control and OA chondrocytes further identified 7 distinct subtypes. Color-coded tsne plot is shown and each chondrocyte subcluster is defined on the right. RegC: regulatory chondrocyte, HomC: homeostatic chondrocyte, ProC: proliferative chondrocyte, preHTC: prehypertrophic chondrocyte, EC: effector chondrocyte, FC: fibrocartilage chondrocyte, HTC: hypertrophic chondrocyte. C. Cell proportions of chondrocytes subclusters in control and OA tissue. RegC subpopulation accounted for a greater proportion in control samples, and FC and preHTC subpopulations accounted for greater proportion in OA samples. D-E. Dot plots showing the expression of indicated markers including HBB, HBA1, and HBA2 for hemoglobin in OA chondrocytes is higher than that in control chondrocytes on the umap map. F-H. The proportions of 7 chondrocytes subpopulations in HBB high-expressing and HBB low-expressing cells, and HBB is highest expressed in ProC, FC and preHTC chondrocyte subgroups

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BMC Molecular and Cell Biology

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