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Fig. 4 | BMC Molecular and Cell Biology

Fig. 4

From: Upregulated dual oxidase 1-induced oxidative stress and caspase-1-dependent pyroptosis reflect the etiologies of heart failure

Fig. 4

DUOX1 knockdown reversed DOX-induced inflammation and abnormal protein expression. The secretion of IL-1β (A) and IL- 18 (B) in the cell supernatant was detected by ELISA. C LDH activity was detected by biochemical method. D Western blot was used to detect the expression of pyroptosis indexes active caspase-1, pro-caspase-1, NLRP3, and GSDMD-N. **p < 0.01 vs. control; ^^p < 0.01 vs. shNC + DOX (2 µmol/L). The blots were cut prior to hybridisation with antibodies during immunoblotting experiments

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BMC Molecular and Cell Biology

ISSN: 2661-8850

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