Fig. 2
From: Structural insights into the non-inhibitory mechanism of the anti-EGFR EgB4 nanobody
EgB4 nanobody binds to the active dimeric EGFR-EGF complex. The ternary complex, consisting of two EGFR, two EGF and two EgB4 molecules is shown in cartoon representation colored by domain. EgB4 binds mainly to EGFR domain I, with smaller contributions from EGFR domain II. EgB4 does not affect EGF binding, nor does it change the structure of the EGFR-EGF complex