Fig. 6

Multiple sequence alignment of RBD across sarbecoviruses. The blue highlighted box denotes RBM. Black asterisks indicate RBD residues that directly bind to ACE2. Red asterisks denote mutations on the binding residues analyzed in this study. The mutated residues are highlighted in light blue and substitutions are marked below. Binding residues in cluster-I, II and III are marked in red, green and blue bars on the top. 1A,B 2A,B and 3A,B indicates the RBD epitopes present in SARS-CoV-2