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Fig. 2 | BMC Molecular and Cell Biology

Fig. 2

From: Comparison of size distribution and (Pro249-Ser258) epitope exposure in in vitro and in vivo derived Tau fibrils

Fig. 2

Effect of sonication on biochemical and functional analysis of K18. a In vitro aggregated K18 fibrils (sonicated and non-sonicated), were analyzed with a PT76/PT76 aggregation selective MSD assay. b, c Seeding capacity of K18 Tau seeds (sonicated and non-sonicated) were investigated by adding different amounts of the preparations to K18-FRET cells, in the absence (panel b) or presence (panel c) of transfection reagent. Induction of aggregation was evaluated and expressed as by percentage of FRET. (∗∗∗p < 0.001; ∗∗∗∗p < 0.0001, two-way ANOVA analysis)

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BMC Molecular and Cell Biology

ISSN: 2661-8850

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