Fig. 1

MSD analysis of recombinant and biological Tau samples. a Three different preparations of K18 aggregates were analyzed using a PT76/PT76 aggregation selective MSD assay and compared against a representative supernatant fraction after ultracentrifugation and against an equivalent amount of monomeric K18. b Comparison of PT76 aggregations specific MSD using two different biological sources, ePHF and P301S spinal cord total extracts