Fig. 6

CD and UV melting curves demonstrating changes in thermal stability upon interaction with G-quadruplex ligands. (a)-(d) CD melting and (e)-(h) UV melting analyses of the Wt-KSHV-GQ and Wt-HCMV-GQ oligonucleotides under the effect of G-quadruplex ligands shows the destabilizing effect of TMPyP4 (50 μM) and stabilizing effect of PDS (10 μM) on the GQs under study. CD melting experiments were performed at a fixed wavelength of 262 nm. ΔTm is defined as the difference between the Tm of the PQS oligonucleotide in the presence and absence of ligand (i.e. TMPyP4 or Pyridostatin)