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Fig. 8 | BMC Molecular and Cell Biology

Fig. 8

From: Exosomal miR-200c-3p negatively regulates the migration and invasion of lipopolysaccharide (LPS)-stimulated colorectal cancer (CRC)

Fig. 8

Exosomal miR-200c-3p promotes HCT-116 apoptosis. Cells were treated with control anti-miRNA or miRNA mimics for 24 h, and then treated with LPS together with mock or exosome inhibitor GW4869 for additional 24 h as indicated in the Fig. a. Representative images of HCT-116 cells labeled with TUNEL (green) and Hoechst 33342 (blue) 24 h after drug treatment in anti-miRNA-transfected group. Scale bar: 50 μm; b. Statistical analysis of TUNEL+/ Hoechst 33342 cell ratio between groups with indicated treatment in (A) (n = 3). Two-way ANOVA was performed. * p < 0.05; ** p < 0.01; *** p < 0.001; c. Representative images of HCT-116 cells labeled with TUNEL (green) and Hoechst 33342 (blue) 24 h after drug treatment in miRNA mimic-transfected group. Scale bar: 50 μm; d. Statistical analysis of TUNEL+/ Hoechst 33342 cell ratio between groups with indicated treatment in (C) (n = 3). Two-way ANOVA was performed. ** p < 0.01; *** p < 0.001

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BMC Molecular and Cell Biology

ISSN: 2661-8850

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