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Table 2 Effect of fibrin γ/γ’ on secretion of uPA and PAI 1 by HMEC-1. Results are expressed as mean ± standard error (SE). Experiments were performed each time in triplicate in three independent experiments

From: Fibrin γ/γ' influences the secretion of fibrinolytic components and clot structure

 

uPA

PAI 1

SN

CL

SN

CL

Basal

0.56 ± 0.09

0.40 ± 0.01

2569 ± 344

1055 ± 85

3% γ/γ’

0.39 ± 0.13

1.73 ± 0.11**ξ

3398 ± 436

770 ± 74

30% γ/γ’

1.06 ± 0.04*

3.21 ± 0.03**

5976 ± 918*

1845 ± 201*

Thrombin

1.04 ± 0.09*

2.42 ± 0.48**

6464 ± 455*

1422 ± 229*

  1. SN: supernatant; CL: cell lysate (1000 cells/μL). uPA and PAI 1 concentrations are in ng/mL
  2. *p < 0.05 when compared to the basal condition and 3% fibrin γ/γ’
  3. **p < 0.05 when compared to the basal condition
  4. ξp < 0.05 when compared to 30% fibrin γ/γ’
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BMC Molecular and Cell Biology

ISSN: 2661-8850

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