Interleukin-1α enhances the aggressive behavior of pancreatic cancer cells by regulating the α6β1-integrin and urokinase plasminogen activator receptor expression

Table 3 Comparison of α₆ integrin and uPAR expression and clinicopathological findings

		Strong co-expression both of α₆ integrin and uPAR		^ap value
		Yes (n = 16)	No (n = 26)	0.011
Gender	Male/Female	11/5	16/10	N.S.
Age (year)		64.4 ± 8.6	64.3 ± 9.5	N.S.
TNM stage	I/II/III/IV	2/1/6/7	7/4/12/3	N.S.
Location	H/B, T	12/4	20/6	N.S.
Liver metastasis	Yes/No	7/9	3/23	0.019
Lymph node matastasis	Yes/No	13/3	13/13	0.045
Cancer cell differentiation	P/Muc/W/Mod	1/0/4/11	2/3/13/8	N.S.
Retroperitoneal invasion	Yes/No	14/2	15/11	0.045
Intrapancreatic nerve invasion	Yes/No	14/2	17/9	N.S.
Lymphatic system invasion	Yes/No	15/1	20/6	N.S.
Venous system invasion	Yes/No	15/1	20/6	N.S.

uPAR, urokinase plasminogen activator receptor; H, head of pancreas; B, body of pancreas; T, tail of pancreas; P, papillary adenocarcinoma; Muc, mucinous carcinoma; W, well-differentiated adenocarcinoma; Mod, moderatery-differentiated adenocarcinoma. The pT, pN, and pM categories were determined according to the TNM classification [19]. The ^ap-values were obtained using the Mann-Whiteny U test. Values of age are given mean ± s.d. N.S., no significant.

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